Iberoamerican Journal of Medicine
Iberoamerican Journal of Medicine
Original article

Incidence of Bacterial Skin Infections in Libya: A Retrospective Population-Based Study

Ahmed Atia, Abdulsalam Ashour, Nosaiba Shaban, Fatima Omar

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Introduction: The global burden of bacterial skin infection is substantial. We aimed to determine the common pathogens causes skin infections and their antimicrobial resistance pattern.
Methods: A retrospective record review of data claimed from the microbiology department at Ber-Ustta Milad skin hospital between Jan 2009 to December 2018 was conducted. The consequence of interest was the antimicrobial sensitivity of bacterial isolates. Chi square was used for statistical analysis.
Results: Out of 1,141 collected samples, a total of 455 isolates of different medically-significant bacteria were analyzed. The most common pathogen was S. aureus (97.14%), followed by E. coli (93.71%), and the least common was Shigella (0.57%). From the various inoculated samples, S. aureus and proteus were highly resistant to penicillin (34.3%, 75% respectively) and ampicillin (28.6%, 62.5% respectively). E. coli was highly resistant to ampicillin (45.12%) and penicillin (35.96%), whereas the lowest resistant was against imipenem (3.05%). While, Pseudomonas was highly resistant to ampicillin and augmentin (62.5%), whereas the lowest resistance rate was marked to erythromycin, sulfamethoxazole and imipenem (25%). Ciprofloxacin, gentamicin and nalidixic acid were the only sensitive agents.
Conclusions: There is a high burden of bacterial resistance to common antibiotics in our population samples. Recognition of the potential resistant strains of pathogen causing skin infection can help in guiding proper choice of antibiotic therapy.


Bacteria; Skin; Infection; Libya


1. Esposito S, Noviello S, Leone S. Epidemiology and microbiology of skin and soft tissue infections. Curr Opin Infect Dis. 2016;29(2):109-15. doi: 10.1097/QCO.0000000000000239.
2. Atia A, Ashour A, Elyounsi N. Trends in skin fungal infection in Tripoli, Libya, during 2007–2015. Ibnosina J Med Biomed Sci. 2019;11(3):116-9. doi: 10.4103/ijmbs.ijmbs_29_19.
3. Enfeksiyonları B, Araştırmalar E. Bacterial Skin Infections: Epidemiology and Latest Research. Turkish Journal of Family Medicine & Primary Care. 2015;9(2):65-74.
4. Vinh DC, Embil JM. Rapidly progressive soft tissue infections. Lancet Infect Dis. 2005;5(8):501-13. doi: 10.1016/S1473-3099(05)70191-2.
5. Jeng A, Beheshti M, Li J, Nathan R. The role of beta-hemolytic streptococci in causing diffuse, nonculturable cellulitis: a prospective investigation. Medicine (Baltimore). 2010;89(4):217-26. doi: 10.1097/MD.0b013e3181e8d635.
6. Moet GJ, Jones RN, Biedenbach DJ, Stilwell MG, Fritsche TR. Contemporary causes of skin and soft tissue infections in North America, Latin America, and Europe: report from the SENTRY Antimicrobial Surveillance Program (1998-2004). Diagn Microbiol Infect Dis. 2007;57(1):7-13. doi: 10.1016/j.diagmicrobio.2006.05.009.
7. World Health Organization. Epidemiology and Management of Common Skin Diseases in Developing Countries (2005). Available from: http://apps.who.int/iris/bitstream/10665/69229/1/WHO_FCH_CAH_05.12_eng.pdf?ua=1 (accessed Oct 2020).
8. Bauer AW, Kirby WMM, Sherris JC, Turck M. Antibiotic susceptibility testing by standardised single disc method. Am J Clin Pathol. 1966;36:493-6. doi: 10.1093/ajcp/45.4_ts.493.
9. Livermore DM, Mushtaq S, Warner M, James D, Kearns A, Woodford N. Pathogens of skin and skin-structure infections in the UK and their susceptibility to antibiotics, including ceftaroline. J Antimicrob Chemother. 2015;70(10):2844-53. doi: 10.1093/jac/dkv179.
10. Kazimoto T, Abdulla S, Bategereza L, Juma O, Mhimbira F, Weisser M, et al. Causative agents and antimicrobial resistance patterns of human skin and soft tissue infections in Bagamoyo, Tanzania. Acta Trop. 2018;186:102-106. doi: 10.1016/j.actatropica.2018.07.007.
11. Rennie RP, Jones RN, Mutnick AH; SENTRY Program Study Group (North America). Occurrence and antimicrobial susceptibility patterns of pathogens isolated from skin and soft tissue infections: report from the SENTRY Antimicrobial Surveillance Program (United States and Canada, 2000). Diagn Microbiol Infect Dis. 2003;45(4):287-93. doi: 10.1016/s0732-8893(02)00543-6.
12. Mohammedamin RS, van der Wouden JC, Koning S, van der Linden MW, Schellevis FG, van Suijlekom-Smit LW, et al. Increasing incidence of skin disorders in children? A comparison between 1987 and 2001. BMC Dermatol. 2006;6:4. doi: 10.1186/1471-5945-6-4.
13. Ansari S, Jha RK, Mishra SK, Tiwari BR, Asaad AM. Recent advances in Staphylococcus aureus infection: focus on vaccine development. Infect Drug Resist. 2019;12:1243-55. doi: 10.2147/IDR.S175014.
14. Ray GT, Suaya JA, Baxter R. Incidence, microbiology, and patient characteristics of skin and soft-tissue infections in a U.S. population: a retrospective population-based study. BMC Infect Dis. 2013;13:252. doi: 10.1186/1471-2334-13-252.
15. Shami A, Al-Mijalli S, Pongchaikul P, Al-Barrag A, AbduRahim S. The prevalence of the culturable human skin aerobic bacteria in Riyadh, Saudi Arabia. BMC Microbiol. 2019;19(1):189. doi: 10.1186/s12866-019-1569-5.
16. Petkovsek Z, Elersic K, Gubina M, Zgur-Bertok D, Starcic Erjavec M. Virulence potential of Escherichia coli isolates from skin and soft tissue infections. J Clin Microbiol. 2009;47(6):1811-7. doi: 10.1128/JCM.01421-08.

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