Can Myrrh Combat COVID-19?
Najat Alyafei
Abstract
This paper reviews the therapeutic effects of Commiphora myrrh in different diseases. It is organized by sub-themed sections: nature and history of myrrh, its use in different cultures, its chemical action, and effect on virus or/and bacteria, benefits of its utilization for respiratory problems and oral diseases.
A literature research for the Myrrh or C. myrrh was performed using Cochrane Library databases and Medline. Forty two papers, including abstracts and full articles published from 2007 to 2020, in the area of interest were reviewed. It was found that Myrrh or C. myrrh is one of the medicinal plants believed to have therapeutic effects in various diseases. It has medicinal properties, such as immunomodulatory, anti-inflammatory, cytotoxic, antioxidant, antimicrobial, hepatoprotective, anti-tumor, anti-ulcer, and analgesic activities. Besides, Myrrh has also shown to have antiviral properties that help in preventing different types of viral diseases. It noticed in the State of Qatar, sales of herbs and Myrrh has escalade since the surgency of COVID-19 cases, so is there a belief in Myrrh's effectiveness to be used during COVID-19? Studying the effectiveness of Myrrh mouthwashes to combat COVID-19 can emerge as a promising avenue in the field of research.
Keywords
References
1. Malosh RE, Martin ET, Ortiz JR, Monto AS. The risk of lower respiratory tract infection following influenza virus infection: A systematic and narrative review. Vaccine. 2018;36(1):141-7. doi: 10.1016/j.vaccine.2017.11.018.
2. Chen SL, Yu H, Luo HM, Wu Q, Li CF, Steinmetz A. Conservation and sustainable use of medicinal plants: problems, progress, and prospects. Chin Med. 2016;11:37. doi: 10.1186/s13020-016-0108-7.
3. Singh R. Medicinal plants: A review. J Plant Sci. 2015;3(1):50-5. doi: 10.11648/j.jps.s.2015030101.18.
4. Shutter stock websites. Myrrh pictures. https://www.shutterstock.com/imagephoto/ close-myrrh-resin-commiphora-myrrha-1289130916.
5. Gadir SA, Ahmed IM. Commiphora myrrha and commiphora Africana essential oils. J Chem Pharm. 2014;6(7):151-6.
6. Germano A, Occhipinti A, Barbero F, Maffei ME. A pilot study on bioactive constituents and analgesic effects of MyrLiq®, a Commiphora myrrha extract with a high furanodiene content. Biomed Res Int. 2017;2017:3804356. doi: 10.1155/2017/3804356.
7. Shameem I. Phytochemical & therapeutic potentials of Murr makki (Commiphora myrrha): A review. Indian J Appl Res. 2018;8(9):102-4.
8. Shen T, Lou HX. Bioactive constituents of myrrh and frankincense, two simultaneously prescribed gum resins in Chinese traditional medicine. Chem Biodivers. 2008;5(4):540-53. doi: 10.1002/cbdv.200890051.
9. Ahamad SR Al-Ghadeer AR, Ali R, Qamar W, Aljarboa S. Analysis of inorganic and organic constituents of myrrh resin by GC-MS and ICP-MS: An emphasis on medicinal assets. Saudi Pharm J. 2017;25(5):788-94. doi: 10.1016/j.jsps.2016.10.011.
10. El Ashry E, Rashed N, Salama O, Saleh A. Components, therapeutic value and uses of myrrh. Pharmazie. 2003;58(3):163-8.
11. Cao B, Wei XC, Xu XR, Zhang HZ, Luo CH, Feng B, et al. Seeing the unseen of the combination of two natural resins, frankincense and myrrh: Changes in chemical constituents and pharmacological activities. Molecules. 2019;24(17). pii: E3076. doi: 10.3390/molecules24173076.
12. Nomicos EY. Myrrh: medical marvel or myth of the Magi?. Holist Nurs Pract. 2007;21(6):308-23. doi: 10.1097/01.hnp.0000298616.32846.34.
13. El-Sherbiny GM, El Sherbiny ET. The effect of Commiphora molmol (Myrrh) in Treatment of Trichomoniasis vaginalis infection. Iran Red Crescent Med J. 2011;13(7):480-6.
14. Abdul-Ghani RA, Loutfy N, Hassan A. Myrrh and trematodoses in Egypt: An overview of safety, efficacy, and effectiveness profiles. Parasitol Int. 2009;58(3):210-4. doi: 10.1016/j.parint.2009.04.006.
15. Al-Jaroudi D, Kaddour O, Al-Amin N. Risks of Myrrh usage in pregnancy. JBRA Assist Reprod. 2016;20(4):257-8. doi: 10.5935/1518-0557.20160050.
16. Khalil N, Fikry S, Salama O. Bactericidal activity of Myrrh extracts and two dosage forms against standard bacterial strains and multidrug-resistant clinical isolates with GC/MS profiling. AMB Express. 2020;10(1):21. doi: 10.1186/s13568-020-0958-3.
17. Kim DG, Bae GS, Choi SB, Jo IJ, Shin JY, Lee SK, et al. Guggulsterone attenuates cerulein-induced acute pancreatitis via inhibition of ERK and JNK activation. Int Immunopharmacol. 2015;26(1):194-202. doi: 10.1016/j.intimp.2015.03.030.
18. Bellezza I, Mierla A, Grottelli S, Marcotullio MC, Messina F, Roscini L, et al. Furanodien-6-one from Commiphora erythraea inhibits the NF-κB signalling and attenuates LPS-induced neuroinflammation. Mol Immunol. 2013;54(3-4):347-54. doi: 10.1016/j.molimm.2013.01.003.
19. Cheng YW, Cheah KP, Lin CW, Li JS, Yu WY, Chang ML, et al. Myrrh mediates haem oxygenase‐1 expression to suppress the lipopolysaccharide‐induced inflammatory response in RAW264.7 macrophages. Journal of Pharmacy and Pharmacology. 2011;63(9):1211-8. doi: 10.1111/j.2042-7158.2011.01329.x.
20. Manjula N, Gayathri B, Vinaykumar KS, Shankernarayanan NP, Vishwakarma RA, Balakrishnan A. Inhibition of MAP kinases by crude extract and pure compound isolated from Commiphora mukul leads to down regulation of TNF-α, IL-1β and IL-2. International Immunopharmacology. 2006;6(2):122-32. doi: 10.1016/j.intimp.2005.07.001.
21. Lv N, Song MY, Kim EK, Park JW, Kwon, KB, Park BH. Guggulsterone, a plant sterol, inhibits NF-κB activation and protects pancreatic β cells from cytokine toxicity. Mol Cell Endocrinol. 2008;289(1-2):49-59. doi: 10.1016/j.mce.2008.02.001.
22. Su S, Wang T, Duan JA, Zhou W, Hua YQ, Tang YP, et al. Antiinflammatory and analgesic activity of different extracts of Commiphora myrrha. J Ethnopharmacol. 2011;134(2):251-8. doi: 10.1016/j.jep.2010.12.003.
23. Yao YQ, Ding X, Jia YC, Huang CX, Wang YZ, Xu YH. Anti-tumor effect of β-elemene in glioblastoma cells depends on p38 MAPK activation. Cancer Lett. 2008;264(1):127-34. doi: 10.1016/j.canlet.2008.01.049.
24. Yeo SK, Ali AY, Hayward OA, Turnham D, Jackson T, Bowen ID, Clarkson R. β‐Bisabolene, a sesquiterpene from the essential oil extract of opoponax (Commiphora guidottii), exhibits cytotoxicity in breast cancer cell lines. Phytother Res. 2016;30(3):418-25. doi: 10.1002/ptr.5543.
25. Shen T, Yuan HQ, Wan WZ, Wang XL, Wang XN, Ji M et al. Cycloartanetype triterpenoids from the resinous exudates of Commiphora opobalsamum. J Nat Prod. 2008;71(1):81-6. doi: 10.1021/np070442p.
26. Shi JJ, Jia XL, Li M, Yang N, Li YP, Zhang X et al. Guggulsterone induces apoptosis of human hepatocellular carcinoma cells through intrinsic mitochondrial pathway. World J Gastroenterol. 2015;21(47):13277-87. doi: 10.3748/wjg.v21.i47.13277.
27. Shishodia S, Azu N, Rosenzweig JA, Jackson DA. Guggulsterone for chemoprevention of cancer. Curr Pharm Des. 2016;22(3):294-306. doi: 10.2174/1381612822666151112153117.
28. Shen T, Li GH, Wang XN, Lou HX. The genus Commiphora: a review of its traditional uses, phytochemistry and pharmacology. J Ethnopharmacol. 2012;142(2):319-30. doi: 10.1016/j.jep.2012.05.025.
29. Singh SV, Choi S, Zeng Y, Hahm ER, Xiao D.. Guggulsterone-Induced Apoptosis in human prostate cancer cells is caused by reactive oxygen intermediate–dependent activation of c-Jun NH2-terminal kinase. Cancer Res. 2007;67(15):7439-49. doi: 10.1158/0008-5472.CAN-07-0120.
30. Mehta AK, Tripathi CD. Commiphora mukul attenuates peripheral neuropathic pain induced by chronic constriction injury of sciatic nerve in rats. Nutr Neurosci. 2015;18(3):97-102. doi: 10.1179/1476830513Y.0000000104.
31. Brochot A, Guilbot A, Haddioui L, Roques C. Antibacterial, antifungal, and antiviral effects of three essential oil blends. Microbiologyopen. 2017;6(4). doi: 10.1002/mbo3.459.
32. Agwaya MS, Vuzi PC, Nandutu AM. Hypoglycemic activity of aqueous root bark extract zanthoxylum chalybeum in alloxan-induced diabetic rats. J Diabetes Res. 2016;2016:8727590. doi: 10.1155/2016/8727590.
33. Shoaib M, Shah I, Ali N, Adhikari A, Tahir MN, Shah SWA et al. Sesquiterpene lactone! a promising antioxidant, anticancer and moderate antinociceptive agent from Artemisia macrocephala jacquem. BMC Complement Altern Med. 2017;17(1):27. doi: 10.1186/s12906-016-1517-y.
34. Zengin H, Baysal AH. Antibacterial and antioxidant activity of essential oil terpenes against pathogenic and spoilage-forming bacteria and cell structureactivity relationships evaluated by SEM microscopy. Molecules. 2014;19(11):17773-98. doi: 10.3390/molecules191117773.
35. Su S, Duan J, Chen T, Huang X, Shang E, Yu L, et al. Frankincense and myrrh suppress inflammation via regulation of the metabolic profiling and the MAPK signaling pathway. Sci Rep. 2015; 5:13668. doi: 10.1038/srep13668.
36. Getasetegn M, Tefera Y. Biological Activities and Valuable Compounds from Five Medicinal Plants. Nat Prod Chem Res. 2016;4(4). doi: 10.4172/2329-6836.1000220.
37. Öktemer T, İpçi K, Muluk NB, Cingi C. A pastille combining myrrh tincture, peppermint oil and menthol to treat the upper airway. ENT Updates. 2015;5(3):128-31. doi: 10.2399/jmu.2015003011.
38. Kalra M, Khatak M, Khatak S. Cold and flu: conventional vs. botanical and nutritional therapy. Int J Drug Dev Res. 2011;3:314-27.
39. Ferrara L. Nutrition and phytotherapy: a winning combination against headache. Int J Med Rev. 2019;6(1):6-13. doi: 10.29252/IJMR-060102.
40. Al-Mobeeriek A. Effects of myrrh on intra-oral mucosal wounds compared with tetracycline- and chlorhexidine-based mouthwashes. Clin Cosmet Investig Dent. 2011;3:53-8. doi: 10.2147/CCIDEN.S24064.
41. Zahid TM, Alblowi JA Anti-Inflammatory and anti-plaque effects of Commiphora myrrh mouthwash: a preliminary pilot clinical study. Open Dent J. 2019;13(1):1-5. doi: 10.2174/1874210601913010001.
42. Bassiouny G, Al-Barrak H. The anti-plaque effect of Miswak and myrrh mouthwashes versus chlorhexidine in the treatment of chronic gingivitis; a comparative clinical trial. Med Sci. 2014;9(33):32-7.
43. Lin CT, Raman R. Comparison of the efficacy between oral rinse, oral gargle, and oral spray. J of Prim Care Community Health. 2012;3(2):80-2. doi: 10.1177/2150131911417185.
44. Alfergani A. Herbal medicine….treatment and heritage. Alwatan newspaper. 2020. Available from: http://www.al-watan.com/newsdetails/
id/72169.
Submitted date:
04/25/2020
Reviewed date:
05/08/2020
Accepted date:
05/15/2020
Publication date:
05/16/2020
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