Iberoamerican Journal of Medicine
Iberoamerican Journal of Medicine
Case Report

Melkersson-Rosenthal syndrome associated to Hashimoto’s thyroiditis

Salem Bouomrani, Ines Lamloum, Rim Mesfar

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Melkersson-Rosenthal syndrome (MRS) is a rare neuromucocutaneous granulomatous disorder classically defined by the triad: fissured tongue (lingua plicata), recurrent orofacial edema, and relapsing facial paralysis. Association with other dysimmune disorders was reported suggesting an immunological origin to this syndrome. The association with autoimmune thyroiditis remains exceptional and unusual.
We report the original case of an MRS associated with Hashimoto autoimmune thyroiditis in a 39-year-old Tunisian man with favorable outcome under thyroxine and systemic glucosteroids.
A dosage of thyroid hormones and a screening for anti-thyroid antibodies would be useful in patients with an MRS.


Melkerson-Rosenthal syndrome; Autoimmune thyroiditis; Hashimoto thyroiditis; Lingua plicata


1. Rivera-Serrano CM, Man LX, Klein S, Schaitkin BM. Melkersson-Rosenthal syndrome: A facial nerve center perspective. J Plast Reconstr Aesthet Surg. 2014;67(8):1050-4. doi: 10.1016/j.bjps.2014.04.014.
2. Elias MK, Mateen FJ, Weiler CR. The Melkersson-Rosenthal syndrome: a retrospective study of biopsied cases. J Neurol. 2013;260(1):138-43. doi: 10.1007/s00415-012-6603-6.
3. Scagliusi P, Sisto M, Lisi S, Lazzari A, D'Amore M. Hashimoto's thyroiditis in Melkersson-Rosenthal syndrome patient: casual association or related diseases? Panminerva Med. 2008;50(3):255-7.
4. Karadurmus N, Fiahin M, Kahraman E, Yilmaz S, Taflçi C, Inal S, et al. Melkersson-Rosenthal syndrome and Hashimoto’s thyroiditis: A case report. Turk Jem. 2009;13:40-2.
5. Aksu K, Kurt E. A case of Melkersson-Rosenthal syndrome associated with autoimmune hypothyroidism. Asthma Allergy Immunol. 2013;11:131-3.
6. Lee YJ, Cheon CK, Yeon GM, Kim YM, Nam SO. Melkersson-Rosenthal syndrome with Hashimoto thyroiditis in a 9-year-old girl: an autoimmune disorder. Pediatr Neurol. 2014;50(5):503-6.
7. Frąckowiak L, Wroński K, Kańczuga-Koda L, Koda M. Melkersson-Rosenthal syndrome in a patient with Hashimoto disease. Prog Health Sci. 2014;l 4(1):269-72.
8. Melkersson E. Ett fall av recidiverande facialispares i samband med angioneurotiskt ödem. Hygiea. 1928;90:737-41.
9. Rosenthal C. Klinisch-erbbiologischer beitrag zur konstitutionspathologie Gemeinsames auftreten von (rezidivierender familiärer) facialislähmung, angio-neurotischem gesichtsödem und lingua plicata in arthritismus-familien. Z Neurol Psychiatr. 1931;131:475-501.
10. Bakshi SS. Melkersson-Rosenthal Syndrome. J Allergy Clin Immunol Pract. 2017;5(2):471-2. doi: 10.1016/j.jaip.2016.09.034.
11. Wehl G, Rauchenzauner M. A Systematic Review of the Literature of the Three Related Disease Entities Cheilitis Granulomatosa, Orofacial Granulomatosis and Melkersson - Rosenthal Syndrome. Curr Pediatr Rev. 2018;14(3):196-203. doi: 10.2174/1573396314666180515113941.
12. Basman A, Gumusok M, Degerli S, Kaya M, Toraman Alkurt M. Melkersson-rosenthal syndrome: a case report. J Istanb Univ Fac Dent. 2017;51(1):42-5. doi : 10.17096/jiufd.96279
13. Lin TY, Chiang CH, Cheng PS. Melkersson-Rosenthal syndrome. J Formos Med Assoc. 2016;115(7):583-4. doi: http://dx.doi.org/10.1016/j.jfma.2015.08.011

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